Scientific research

The Laboratory of Biochemical Analytics and Nanodiagnostics was established in December 2017 as part of the reorganization of the structure of the Department of Chemistry, although it has been successfully operating since January 2014 (formerly the Laboratory of Biochemical Analytics). The research topics carried out in the Laboratory are the study of substrate specificity of proteolytic enzymes by combinatorial chemistry methods. The main objects of research are proteinases isolated from human blood cells - neutrophils (including the newly discovered NSP4), and those involved in wound healing from the kallikrein family. By chemical synthesis, we obtain efficient and selective peptides containing fluorescent markers in the sequence. In cooperation with medical centers, we determine the activity level of these enzymes in patients, which can contribute to proper diagnosis.

The aforementioned wound healing process is another research topic conducted by members of the Laboratory. We design and synthesize peptides whose sequence consists of a peptide that exhibits antimicrobial properties and a peptide that stimulates proliferation. We test the conjugates thus obtained on a human skin model and determine their ability to inhibit bacterial growth.