Research

Laboratory of Medical Chemistry

	Prof. dr hab. Sylwia Rodziewicz-Motowidło Human Cystatin C - conformational studies using NMR and molecular dynamics techniques Study of interactions of human cystatin C with antibodies as potential inhibitors of amyloidosis Peptide antibiotics and peptidomimetics - design, synthesis, conformational studies Peptides with pro-regenerative and neuroprotective properties - design, synthesis and physicochemical studies Design, synthesis and study of peptides with potential anticancer properties Peptides and peptidomimetics in viral diseases
	Dr hab. Elżbieta Jankowska, prof. UG Search for effective modulators (stimulators/inhibitors) of the activity of the multi-subunit enzyme complex - proteasome Study of mechanisms of protein aggregation. Structural studies of peptides and proteins.
	Dr hab. Aneta Szymańska, prof.UG Studies of dimerization, oligomerization and fibrillation processes of amyloidogenic peptides and proteins (e.g., human cystatin C, hCC; amyloidogenic plasma protein A, SAA, beta-amyloid peptide, Abeta). Studies of factors affecting the conformational stability of cystatin C Influence of environmental factors on the oligomerization process of cystatin C Effect of metal ions on amyloidogenic properties of proteins
	Dr hab. Magdalena Wysocka, prof. UG Selection by combinatorial chemistry methods of peptide fluorescent substrates of proteolytic enzymes. Design and chemical synthesis of fluorescently labeled low-molecular-weight proteinase inhibitors and their use as probes of enzymatic activity.
	Dr Eng. Irena Bylińska Synthesis of organic compounds with emphasis on the search for new fluorescent tracers; Study of spectral and photophysical properties of aromatic organic compounds ; Fluorescence microscopy with special emphasis on imaging of the cell interior using the FLIM technique.
	Dr Maria Dzierżyńska Design, synthesis and biological studies of antibacterial and antiviral compounds along with the study of their mechanism of action; Regeneration-stimulating peptides-Synthesis and studies of fibroblast growth stimulation.
	Dr Katarzyna Guzow Synthesis of new fluorescent tracers Search for new peptide antibiotics containing 3-(2-benzoxazol-5-yl)alanine derivatives Study of spectral and photophysical properties and biological activity of the obtained compounds
	Dr Marta Orlikowska Structural studies of HVEM/CD160 signaling receptors as potential targets for immunotherapy; Studies of the degradation process of protein aggregates by determining the spatial structure of heat shock protein Hsp104. Determination of spatial structures of proteins and their complexes by structural roentgenography;
	Dr Marta Spodzieja Design and synthesis of inhibitors of BTLA-HVEM, CD160-HVEM, PD1-PDL1 protein complex formation with potential application in cancer immunotherapy.
	Dr Ewa Wieczerzak Preparation of proteins by chemical ligation method; Design, synthesis and biological studies of peptides and peptidomimetics with potential therapeutic activity (cysteine protease inhibitors, proteasome inhibitors/activators). Search for leading structures to design compounds with potential therapeutic activity (e.g., proteasome modulators) among substances of natural origin
	Dr Julia Witkowska Structural studies of peptides and proteins. Search for stimulators and inhibitors of proteasome activity. Study of interactions of the proteasome with modulators of its activity by means of structural roentgenography. Study of enzymatic kinetics and activity of biologically active peptides.

Laboratory of Structural Biochemistry

Dr hab. Zbigniew Kaczyński, prof. UG

Structural studies of polysaccharides of potential importance to human health.
Extraction of polysaccharides from biological material, purification by molecular sieving, analysis of the corresponding products using gas chromatography (GC), mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Submitted on Saturday, 1. March 2014 - 21:14 by Aneta Szymańska Changed on Saturday, 3. June 2023 - 20:35 by Aneta Szymańska